Research Authors

Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%

Top Medical Research Studies

We examined the potential of vitamin D as a treatment for yeast infections, specifically targeting the troublesome Candida species. The study employed both in vitro and in vivo methods to assess the antifungal capabilities of vitamin D, revealing promising results in inhibiting the growth of these fungi.

Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.

Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.

These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
Read More
8
Vitamin D reduces Candida infections
We investigated the effectiveness of vitamin D in reducing Candida infections in children admitted to the pediatric intensive care unit (PICU). This study included 416 children between the ages of 12 months to 5 years who were receiving broad-spectrum antibiotics. They were divided into two groups: one group received a plain yogurt drink (the placebo), while the other was given yogurt enriched with vitamin D at a daily dose of 300 IU.

Our primary focus was on whether vitamin D could decrease instances of Candida colonization, which we measured using rectal swabs 14 days after enrolling the patients. We also looked at secondary outcomes, including Candida growth in blood and urine. The results showed that the children who received the vitamin D yogurt drink had significantly lower cases of Candida infections, both in urine and blood, compared to those who didn't get the vitamin D.

Moreover, those in the vitamin D group had a shorter average stay in the PICU. However, the rate of mortality was similar between both groups, indicating that while vitamin D supplementation helped reduce infections, it didn't affect patient survival rates. Overall, our findings suggest that vitamin D can be an effective strategy for reducing Candida infections in critically ill children undergoing antibiotic treatment.
Read More
8
Vitamin D's potential against yeast
We explored how vitamin D3 could potentially affect yeast infections, particularly caused by Candida albicans. The study revealed that in controlled laboratory conditions, vitamin D3 showed a significant inhibitory effect on various strains of bacteria and fungi, including Staphylococcus aureus, Streptococcus pyogenes, Klebsiella pneumoniae, Escherichia coli, and Candida albicans.

The researchers found that when vitamin D3 was present at a concentration of 50,000 to 90,000 IU/ml, these organisms were either killed or experienced marked growth inhibition. This indicates that vitamin D3 might hold promise as an adjunct treatment for yeast infections, but further research would be necessary to fully understand its effectiveness in real-world scenarios.

Overall, this study sheds light on the potential antimicrobial properties of vitamin D3, highlighting its capacity to fight off certain pathogens, including yeast. However, it’s crucial to continue exploring these findings to confirm their applicability beyond the lab environment.
Read More

Most Useful Reviews

9
Reduced infections
1 people found this helpful
Good vitamin D at a reasonable price. I store it in the fridge and take it with Omega in the mornings. We consume it all year round. Since starting vitamin D, my children's frequent acute respiratory viral infections have significantly decreased, and they rarely miss school. Even when they catch colds, they recover easily without complications. I highly recommend it!
Read More
9
Better overall health
1 people found this helpful
An excellent product for various health concerns! My husband takes 4,000 IU daily for his high blood pressure, and since incorporating D-3, his levels are at an all-time low! My 16-year-old daughter, who has Lyme disease, takes 3,000 IU, which has significantly improved her circulation and mood. I also take 3,000 IU each day, and it has made a remarkable difference in my physical and emotional well-being, alleviating my seasonal affective disorder. The product is fantastic!
Read More
7.5
Improved immunity
1 people found this helpful
This is beneficial for precautions against coronavirus! People with high vitamin D levels are actively taking it, as the severity of coronavirus infection appears less. I haven’t experienced a severe cold since I began this routine. It's advisable considering the high costs of domestic supplements. I appreciate that it includes 2000iu for efficient intake.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
  • All Researches
We examined the potential of vitamin D as a treatment for yeast infections, specifically targeting the troublesome Candida species. The study employed both in vitro and in vivo methods to assess the antifungal capabilities of vitamin D, revealing promising results in inhibiting the growth of these fungi.

Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.

Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.

These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
Read More
We explored how vitamin D interacts with the immune response to yeast infections, specifically focusing on a systemic fungal disease called paracoccidioidomycosis (PCM). This study examined whether vitamin D could enhance the activity of certain cytokines, notably IL-15 and IL-32, which are known to impact immune function.

Our findings revealed that IL-32 is present in lesions from PCM patients and that it can be induced in peripheral blood mononuclear cells (PBMCs) after exposure to P. brasiliensis antigens. The IL-32γ isoform was primarily expressed, suggesting a specific immune response to the infection. However, while IL-15 strongly stimulated IL-32 production, this increase in fungal control required the presence of high levels of vitamin D.

Notably, P. brasiliensis itself did not significantly induce IL-32 when PBMCs were exposed to intact yeast cells, but it did show a positive effect with heat-killed or sonicated yeast. These insights suggest that vitamin D, in conjunction with IL-15 and IL-32, plays a role in combating fungal infections, emphasizing that specific components from the fungus are needed to activate this immune response.

Overall, our results highlight the potential importance of vitamin D in enhancing immune responses against yeast infections through the IL-15/IL-32 pathway, but further investigations are necessary to fully understand its role.
Read More
8
Vitamin D reduces Candida infections
We investigated the effectiveness of vitamin D in reducing Candida infections in children admitted to the pediatric intensive care unit (PICU). This study included 416 children between the ages of 12 months to 5 years who were receiving broad-spectrum antibiotics. They were divided into two groups: one group received a plain yogurt drink (the placebo), while the other was given yogurt enriched with vitamin D at a daily dose of 300 IU.

Our primary focus was on whether vitamin D could decrease instances of Candida colonization, which we measured using rectal swabs 14 days after enrolling the patients. We also looked at secondary outcomes, including Candida growth in blood and urine. The results showed that the children who received the vitamin D yogurt drink had significantly lower cases of Candida infections, both in urine and blood, compared to those who didn't get the vitamin D.

Moreover, those in the vitamin D group had a shorter average stay in the PICU. However, the rate of mortality was similar between both groups, indicating that while vitamin D supplementation helped reduce infections, it didn't affect patient survival rates. Overall, our findings suggest that vitamin D can be an effective strategy for reducing Candida infections in critically ill children undergoing antibiotic treatment.
Read More
8
Vitamin D modulates yeast infection response
We set out to understand how vitamin D, specifically a form called 1,25-dihydroxyvitamin D3, influences the immune response to Candida albicans, a common yeast infection. Using peripheral blood mononuclear cells, we stimulated these immune cells with the yeast and vitamin D to observe the effects on cytokine production, which are crucial for regulating immune responses.

Our findings revealed that the presence of vitamin D shifted the immune response towards a more anti-inflammatory profile. This was characterized by a decrease in several inflammatory cytokines, such as IL-6, TNFα, IL-17, and IFNγ, while boosting the production of IL-10, which is known for its anti-inflammatory properties. Interestingly, vitamin D also appeared to suppress the expression of various receptors that normally recognize and respond to the yeast.

We conducted further tests to evaluate how seasonal changes affected these immune responses. It turned out that during summer, when levels of vitamin D in the body are generally higher, the production of some pro-inflammatory cytokines was notably reduced. This suggests that higher levels of vitamin D can indeed modulate immune function against yeast infections.

Overall, our study highlights a potential therapeutic role for vitamin D in managing infections like Candida albicans by promoting an anti-inflammatory immune response. The impact of seasonal variations adds an interesting layer to our understanding of how vitamin D might influence our defenses against infections.
Read More
8
Vitamin D's potential against yeast
We explored how vitamin D3 could potentially affect yeast infections, particularly caused by Candida albicans. The study revealed that in controlled laboratory conditions, vitamin D3 showed a significant inhibitory effect on various strains of bacteria and fungi, including Staphylococcus aureus, Streptococcus pyogenes, Klebsiella pneumoniae, Escherichia coli, and Candida albicans.

The researchers found that when vitamin D3 was present at a concentration of 50,000 to 90,000 IU/ml, these organisms were either killed or experienced marked growth inhibition. This indicates that vitamin D3 might hold promise as an adjunct treatment for yeast infections, but further research would be necessary to fully understand its effectiveness in real-world scenarios.

Overall, this study sheds light on the potential antimicrobial properties of vitamin D3, highlighting its capacity to fight off certain pathogens, including yeast. However, it’s crucial to continue exploring these findings to confirm their applicability beyond the lab environment.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Reduced infections
1 people found this helpful
Good vitamin D at a reasonable price. I store it in the fridge and take it with Omega in the mornings. We consume it all year round. Since starting vitamin D, my children's frequent acute respiratory viral infections have significantly decreased, and they rarely miss school. Even when they catch colds, they recover easily without complications. I highly recommend it!
Read More
9
Better overall health
1 people found this helpful
An excellent product for various health concerns! My husband takes 4,000 IU daily for his high blood pressure, and since incorporating D-3, his levels are at an all-time low! My 16-year-old daughter, who has Lyme disease, takes 3,000 IU, which has significantly improved her circulation and mood. I also take 3,000 IU each day, and it has made a remarkable difference in my physical and emotional well-being, alleviating my seasonal affective disorder. The product is fantastic!
Read More
7.5
Improved immunity
1 people found this helpful
This is beneficial for precautions against coronavirus! People with high vitamin D levels are actively taking it, as the severity of coronavirus infection appears less. I haven’t experienced a severe cold since I began this routine. It's advisable considering the high costs of domestic supplements. I appreciate that it includes 2000iu for efficient intake.
Read More

Frequently Asked Questions

9
Reduced infections
1 people found this helpful
Good vitamin D at a reasonable price. I store it in the fridge and take it with Omega in the mornings. We consume it all year round. Since starting vitamin D, my children's frequent acute respiratory viral infections have significantly decreased, and they rarely miss school. Even when they catch colds, they recover easily without complications. I highly recommend it!
9
Better overall health
1 people found this helpful
An excellent product for various health concerns! My husband takes 4,000 IU daily for his high blood pressure, and since incorporating D-3, his levels are at an all-time low! My 16-year-old daughter, who has Lyme disease, takes 3,000 IU, which has significantly improved her circulation and mood. I also take 3,000 IU each day, and it has made a remarkable difference in my physical and emotional well-being, alleviating my seasonal affective disorder. The product is fantastic!
7.5
Improved immunity
1 people found this helpful
This is beneficial for precautions against coronavirus! People with high vitamin D levels are actively taking it, as the severity of coronavirus infection appears less. I haven’t experienced a severe cold since I began this routine. It's advisable considering the high costs of domestic supplements. I appreciate that it includes 2000iu for efficient intake.
We examined the potential of vitamin D as a treatment for yeast infections, specifically targeting the troublesome Candida species. The study employed both in vitro and in vivo methods to assess the antifungal capabilities of vitamin D, revealing promising results in inhibiting the growth of these fungi.

Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.

Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.

These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
8
Vitamin D modulates yeast infection response
We set out to understand how vitamin D, specifically a form called 1,25-dihydroxyvitamin D3, influences the immune response to Candida albicans, a common yeast infection. Using peripheral blood mononuclear cells, we stimulated these immune cells with the yeast and vitamin D to observe the effects on cytokine production, which are crucial for regulating immune responses.

Our findings revealed that the presence of vitamin D shifted the immune response towards a more anti-inflammatory profile. This was characterized by a decrease in several inflammatory cytokines, such as IL-6, TNFα, IL-17, and IFNγ, while boosting the production of IL-10, which is known for its anti-inflammatory properties. Interestingly, vitamin D also appeared to suppress the expression of various receptors that normally recognize and respond to the yeast.

We conducted further tests to evaluate how seasonal changes affected these immune responses. It turned out that during summer, when levels of vitamin D in the body are generally higher, the production of some pro-inflammatory cytokines was notably reduced. This suggests that higher levels of vitamin D can indeed modulate immune function against yeast infections.

Overall, our study highlights a potential therapeutic role for vitamin D in managing infections like Candida albicans by promoting an anti-inflammatory immune response. The impact of seasonal variations adds an interesting layer to our understanding of how vitamin D might influence our defenses against infections.
8
Vitamin D reduces Candida infections
We investigated the effectiveness of vitamin D in reducing Candida infections in children admitted to the pediatric intensive care unit (PICU). This study included 416 children between the ages of 12 months to 5 years who were receiving broad-spectrum antibiotics. They were divided into two groups: one group received a plain yogurt drink (the placebo), while the other was given yogurt enriched with vitamin D at a daily dose of 300 IU.

Our primary focus was on whether vitamin D could decrease instances of Candida colonization, which we measured using rectal swabs 14 days after enrolling the patients. We also looked at secondary outcomes, including Candida growth in blood and urine. The results showed that the children who received the vitamin D yogurt drink had significantly lower cases of Candida infections, both in urine and blood, compared to those who didn't get the vitamin D.

Moreover, those in the vitamin D group had a shorter average stay in the PICU. However, the rate of mortality was similar between both groups, indicating that while vitamin D supplementation helped reduce infections, it didn't affect patient survival rates. Overall, our findings suggest that vitamin D can be an effective strategy for reducing Candida infections in critically ill children undergoing antibiotic treatment.
We set out to examine how vitamin D, specifically in the form of calcitriol, could work as a potential treatment for yeast infections caused by Candida species. Through a method called virtual screening, we identified calcitriol along with a few other drugs as possible inhibitors of an enzyme known as oxidosqualene cyclase (OSC) in Candida albicans. This enzyme plays a vital role in the synthesis of ergosterol, which is important for the fungal cell membrane.

To further explore calcitriol's effectiveness, we conducted laboratory tests against strains of Candida. The results were promising; calcitriol demonstrated antifungal activity against both C. albicans and C. tropicalis. This suggested that calcitriol could be a valuable candidate for future antifungal therapies targeting OSC.

Overall, our findings shine a light on the potential of vitamin D as a novel approach to treat yeast infections. By repurposing an existing drug, we could pave the way for more effective antifungal options for patients, especially those who are immunocompromised and at higher risk for these infections.

References

  1. Lei J, Xiao W, Zhang J, Liu F, Xin C, et al. Antifungal activity of vitamin D against Candida albicans in vitro and in vivo. Microbiol Res. 2022;265:127200. 10.1016/j.micres.2022.127200
  2. Guimarães de Matos G, Barroso de Figueiredo AM, Diniz Gonçalves PH, Luiz de Lima Silva L, Bastista AC, et al. Paracoccidioidesbrasiliensis induces IL-32 and is controlled by IL-15/IL-32/vitamin D pathway in vitro. Microb Pathog. 2021;154:104864. 10.1016/j.micpath.2021.104864
  3. Xie J, Zhu L, Zhu T, Jian Y, Ding Y, et al. Vitamin D-supplemented yogurt drink reduces Candida infections in a paediatric intensive care unit: a randomised, placebo-controlled clinical trial. J Hum Nutr Diet. 2019;32:512. 10.1111/jhn.12634
  4. Rabelo VW, Viegas DJ, Tucci EMN, Romeiro NC, Abreu PA. Virtual screening and drug repositioning as strategies for the discovery of new antifungal inhibitors of oxidosqualene cyclase. J Steroid Biochem Mol Biol. 2019;185:189. 10.1016/j.jsbmb.2018.09.001
  5. Khoo AL, Chai LY, Koenen HJ, Kullberg BJ, Joosten I, et al. 1,25-dihydroxyvitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responses. J Infect Dis. 2011;203:122. 10.1093/infdis/jiq008
  6. Feindt E, Ströder J. [Studies on the antimicrobial effect of vitamin D (author's transl)]. Klin Wochenschr. 1977;55:507.
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